Name:
Investigating the blood-brain barrier
Description:
Investigating the blood-brain barrier
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Duration:
T00H02M19S
Embed URL:
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Content URL:
https://cadmoreoriginalmedia.blob.core.windows.net/13269b02-abb8-4335-8d3e-cc1fa83fd60a/NeuroscienceV3.mp4?sv=2019-02-02&sr=c&sig=wIL9l1YuPc7eHUplPu9aCr1tJ2kLwLd%2BMwACpAYvFVs%3D&st=2024-12-04T08%3A19%3A53Z&se=2024-12-04T10%3A24%3A53Z&sp=r
Upload Date:
2021-11-15T00:00:00.0000000
Transcript:
Language: EN.
Segment:0 .
[MUSIC PLAYING]
ABIGAIL SAWYER: The blood-brain barrier surrounds and protects the brain, controlling the entry of cells, ions, and molecules into its interstitial fluid from blood plasma. It is a membranic structure composed of the endothelial cells that comprise the walls of brain capillaries. These cells are physically held together in tight junctions, making them the least permeable capillaries in the body. The blood-brain barrier regulates the entry of toxins to the brain, including pathogens and urea.
ABIGAIL SAWYER: However, it is ineffective against fat-soluble molecules, such as alcohol and nicotine. Due to this tight regulation, it can be a challenge to develop effective therapeutics that can permeate the blood-brain barrier to treat diseases of the Central Nervous System, or CNS. Another challenge with treating CNS diseases is that our understanding of the function and influence of the blood-brain barrier in such diseases is currently limited.
ABIGAIL SAWYER: Its location makes it difficult to study. Therefore, novel techniques and methods are required to afford further insight. The blood-brain barrier is thought to play a crucial role in the onset and development of CNS diseases such as Alzheimer's and Parkinson's. Degradation and therefore leakage of the blood-brain barrier have been shown in both post-mortem and MRI studies in those with the diseases.
ABIGAIL SAWYER: The extent to which blood-brain barrier dysfunction influences Alzheimer's and Parkinson's disease causation continues to be debated, and there are currently many hypotheses. For the development of novel therapeutics, it is important to gain deeper insights into the blood-brain barrier and uncover how it is implicated in CNS disease mechanisms. Keep up-to-date with this In Focus to find out how the blood-brain barrier can be further elucidated, and learn more about how newer technologies, like single cell and spatial analysis, can help unlock the mysteries of the nervous system and the blood-brain barrier.
ABIGAIL SAWYER: You can catch up at www.biotechniques.com, and follow us on Facebook, Twitter, and LinkedIn for all the latest updates.