Name:
The EXPLORER-HCM study: mavacamten for obstructive HCM
Description:
The EXPLORER-HCM study: mavacamten for obstructive HCM
Thumbnail URL:
https://cadmoremediastorage.blob.core.windows.net/33cb637c-298b-42b6-bb5a-1be2e2656d9f/videoscrubberimages/Scrubber_67.jpg
Duration:
T00H01M37S
Embed URL:
https://stream.cadmore.media/player/33cb637c-298b-42b6-bb5a-1be2e2656d9f
Content URL:
https://cadmoreoriginalmedia.blob.core.windows.net/33cb637c-298b-42b6-bb5a-1be2e2656d9f/EXPLORER HCM Animated Video.mp4?sv=2019-02-02&sr=c&sig=iI8OJn%2FHOOtJNhHJ9FKY%2B9edH7BUSv4Lkz60HhRfryk%3D&st=2024-11-23T04%3A22%3A36Z&se=2024-11-23T06%3A27%3A36Z&sp=r
Upload Date:
2021-05-28T00:00:00.0000000
Transcript:
Language: EN.
Segment:1 The EXPLORER-HCM study: mavacamten for obstructive HCM.
SPEAKER: Hypertrophic cardiomyopathy, or HCM, is a disease where the heart muscle becomes abnormally thick and stiff, making it harder for the heart to pump blood. In HCM there are too many connections or cross bridges between actin and myosin proteins, which produces excess work and makes it harder for the muscle to relax. Common symptoms of HCM include shortness of breath, palpitations, chest pain, lightheadedness, fainting, and fatigue.
SPEAKER: Mavacamten is a once a day oral investigational therapy for obstructive HCM. Mavacamten targets the underlying mechanism of HCM, by inhibiting and therefore, reducing the number of actin myocin cross-bridges. It improves how the heart relaxes and fills with blood, reduces how hard it works to pump, and reduces how much energy is used for each heartbeat. The EXPLORER-HCM study compared mavacamten treatment to a placebo in people with symptomatic obstructive HCM.
SPEAKER: Results showed that compared to placebo, mavacamten improved heart function by decreasing obstruction of blood flow to the body. Mavacamten improved symptoms and how people felt about their overall health. It also improved exercise capacity and reduced biomarkers of heart wall stress and injury. These are promising results for people with HCM. And Mavacamten side effects were generally mild and similar to placebo.
SPEAKER: [MUSIC PLAYING]