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Name:
10.3171/2024.4.FOCVID2436
Description:
10.3171/2024.4.FOCVID2436
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https://cadmoremediastorage.blob.core.windows.net/52dc450e-6967-4a11-b924-569097f0b9fa/thumbnails/52dc450e-6967-4a11-b924-569097f0b9fa.jpeg
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T00H10M21S
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https://stream.cadmore.media/player/52dc450e-6967-4a11-b924-569097f0b9fa
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https://cadmoreoriginalmedia.blob.core.windows.net/52dc450e-6967-4a11-b924-569097f0b9fa/13. 24-36.mp4?sv=2019-02-02&sr=c&sig=hC36QjoE7Nrn%2Bq3AybidEFPTEVmc0gYSRWoDBRj%2BZSM%3D&st=2026-04-26T07%3A12%3A11Z&se=2026-04-26T09%3A17%3A11Z&sp=r
Upload Date:
2026-04-26T07:17:11.6678619Z
Transcript:
Language: EN.
Segment:0 .
[MUSIC PLAYING]
SPEAKER: Hemispherectomy is a powerful tool
SPEAKER: in the treatment of drug-resistant hemispheric epilepsy. The operation has been modified by numerous surgeons to reduce complications and morbidity, namely hydrocephalus and superficial cerebral hemosiderosis. Here, we will describe the functional or disconnective technique which provides surgical disconnection of the hemisphere while minimizing tissue resection. Technique selection should be guided by specific patient anatomy and underlying pathology.
SPEAKER: Consideration should be given to the best approach to achieve optimal visualization of the connected structures and their subsequent disconnection. All hemispherectomy approaches should be considered disconnective procedures with varying levels of tissue sparing. As such, technique choice should be made in order to ensure optimal disconnection is completed, as this is the strongest predictor of patient outcome and seizure freedom.
SPEAKER: The patient is placed under general endotracheal anesthesia. An arterial line, indwelling catheter, and large-bore venous access are placed by the anesthesia and nursing teams. Intravenous steroids and antibiotics are administered within an hour of skin incision. Electrocorticography, cortical stimulation, and neuromonitoring are not routinely used during surgery. Blood products should be placed on hold for the operating room, as especially in pediatric patients, operative blood loss can lead to hemodynamic instability and coagulopathy.
SPEAKER: We position the patient supine with the head in a 90-degree lateral turn with a support under the ipsilateral shoulder.
SPEAKER: The vertex is placed slightly down to allow access to the mesial temporal and interhemispheric structures. A large hemispheric incision is planned, either T-shaped or barn door or question mark in fashion. The incision extends ventrally to the zygoma to allow full exposure of the temporal lobe. Here we present a right-sided approach. The skin and temporalis can be reflected together or separately to expose a craniotomy site that includes the coronal suture anteriorly, the asterion posteriorly, the midconvexity in the dorsal extent, and to the floor of the middle fossa ventrally.
SPEAKER: This patient has a preexisting ventricular shunt, which is preserved, disconnected, and protected. The bone flap is turned to maximize visualization, which ensures adequate disconnection and minimized tissue injury from extensive retraction.
SPEAKER: The dura is tacked to the bone to prevent the formation of postoperative epidural collections. The dura is opened in C-shaped fashion and reflected along a frontal temporal base. Five major disconnections are needed in order to successfully complete the operation. Resection of the medial temporoparietal lobe, disruption of the corona radiata and temporal white matter, a corpus callosotomy, disconnection of the basal frontal connections, and finally, removal of the insula.
SPEAKER: The sylvian fissure is identified. A pial cut is made in the dorsal superior temporal gyrus, and the temporal lobe is elevated from the pia overlying the vessels within the sylvian fissure. Here, the lateral temporal lobe is elevated from the insula laterally and the inferior circular sulcus is identified below. The frontal lobe is then gently retracted to expose the superior circular sulcus.
SPEAKER: This connects back to the inferior circular sulcus, which serves as a landmark for the temporal horn of the lateral ventricle. The temporal horn is opened to expose the mesial temporal structures. Cottonoids are used to prevent blood from entering the contralateral ventricular system. As the ventricle is exposed, several key anatomic landmarks are identified, including the hippocampus, amygdala, and choroidal point.
SPEAKER: The ventricle is unroofed completely to expose the rest of the hippocampal body and tail as it transitions into the fornix. Above the sylvian fissure, the corona radiata is divided to enter the lateral ventricle.
SPEAKER: Here, the corpus callosum can be visualized at the junction of the septum pellucidum and the ventricular roof. Again, a small cotton ball can be used to plug the foramen of Monro. The frontal parietal white matter should be resected posteriorly and around the posterior insula to connect the infra-sylvian dissection.
SPEAKER: Attention is then turned to the horizontal frontal fibers which lie anterior and superior to the insula. Attention to this area is particularly important, as it is frequently a site of residual connection that requires reoperation, especially when malformative of cortex is present in this region. The posterior basal frontal lobe is removed to expose the orbitofrontal pia, which is then coagulated and opened down to the olfactory nerve.
SPEAKER: Here, the gyrus rectus is identified and aspirated until the pia of the contralateral gyrus rectus is seen. Here, the origin of the A2 branches can be visualized and followed to the genu of the corpus callosum, which generally occurs as the arteries curve posteriorly into the A3 segment. This anatomical boundary is important to note, as it allows for ample disconnection at the genu without injurious extension into the hypothalamus ventral to the genu.
SPEAKER: Dissection should be subpial with preservation of as much as the vascular supply to the cortex left behind as possible to avoid postoperative issues with stroke and brain swelling. The curve of the genu can be confusing, and one must remember that two layers of gray matter and pia will be encountered during its aspiration. The corpus callosum should be disconnected at the junction of the roof of the ventricle and the septum pellucidum.
SPEAKER: Aspiration of the ipsilateral cingulate ensures a complete disconnection and makes postoperative imaging easier to interpret. The inferior edge of the falx is often seen and serves as an excellent anatomic reference during callosotomy. Branches of the anterior cerebral artery should be spared whenever possible. The surgeon must respect both arteries above the callosum, as it is difficult to tell which artery supplies the affected hemisphere.
SPEAKER: Care should be taken to completely disconnect the splenium. Review of the individual callosal anatomy, as seen on the preoperative MRI, helps as the callosal anatomy can vary depending on the etiology of the epilepsy. Attention is then turned to the mesial temporal structures which were previously exposed.
SPEAKER: The choroidal point is identified and the amygdala is dissected along the plane connecting the M1 segment of the MCA and the choroidal point. The remaining parahippocampus and uncus are then removed via subpial aspiration, being careful not to violate the mesial pia or injure the structures in the perimesencephalic cistern. The hippocampus is then reflected inferiorly and the choroidal fissure opened by aspiration of the fimbria and fornix.
SPEAKER: At this point, the hippocampal sulcus is identified and developed with further aspiration of the dentate gyrus. Once visualized, the hippocampal sulcus, including the hippocampal arteries and veins, are coagulated and divided. The hippocampus is then removed in one segment for pathological study. In this case, we now remove the lateral neocortical structures to allow further exposure of the posterior mesial temporal region.
SPEAKER: The lateral neocortex can also be removed early on during the exposure of the mesial structures at the beginning of the case by connecting sagittal and coronal cuts through the lateral ventricular sulcus along the collateral eminence. This can be an important tool to aid in surgical visualization and help to guarantee an adequate disconnection. The tail of the hippocampus is then followed posteriorly around the midbrain into the forniceal columns where it is truncated.
SPEAKER: Above the forniceal columns, note the relation of the splenium. This anatomical relationship allows inspection and complete disconnection of the callosum. The final step of the operation is removal of the insula.
SPEAKER: With care to preserve the vessels overlying, the gyri are gently aspirated with suction. Excessive removal of tissue can lead to disruption of the basal ganglia deep to the insula, which is usually identified by its speckled appearance and the incidence of diffuse bleeding on aspiration. Hemostasis is achieved with care to remove as much blood from the foramen of Monro as possible.
SPEAKER: A ventricular drain is placed into the subdural space in the ventricular cavity. The dura is then closed primarily. The shunt is reconnected. For patients with adjustable shunts, we typically turn the shunt to the highest resistance to decrease postoperative fluid flow through the system until the ventricular drain is removed between postoperative day 3 through 5.
SPEAKER: The bone is replaced and the muscle is reapproximated. A subgaleal drain is also placed and the skin is then closed. Patients are placed on an extended steroid taper after surgery and antiseizure medications are restarted at preoperative doses.
Segment:0 .
[MUSIC PLAYING]
SPEAKER: Hemispherectomy is a powerful tool
SPEAKER: in the treatment of drug-resistant hemispheric epilepsy. The operation has been modified by numerous surgeons to reduce complications and morbidity, namely hydrocephalus and superficial cerebral hemosiderosis. Here, we will describe the functional or disconnective technique which provides surgical disconnection of the hemisphere while minimizing tissue resection. Technique selection should be guided by specific patient anatomy and underlying pathology.
SPEAKER: Consideration should be given to the best approach to achieve optimal visualization of the connected structures and their subsequent disconnection. All hemispherectomy approaches should be considered disconnective procedures with varying levels of tissue sparing. As such, technique choice should be made in order to ensure optimal disconnection is completed, as this is the strongest predictor of patient outcome and seizure freedom.
SPEAKER: The patient is placed under general endotracheal anesthesia. An arterial line, indwelling catheter, and large-bore venous access are placed by the anesthesia and nursing teams. Intravenous steroids and antibiotics are administered within an hour of skin incision. Electrocorticography, cortical stimulation, and neuromonitoring are not routinely used during surgery. Blood products should be placed on hold for the operating room, as especially in pediatric patients, operative blood loss can lead to hemodynamic instability and coagulopathy.
SPEAKER: We position the patient supine with the head in a 90-degree lateral turn with a support under the ipsilateral shoulder.
SPEAKER: The vertex is placed slightly down to allow access to the mesial temporal and interhemispheric structures. A large hemispheric incision is planned, either T-shaped or barn door or question mark in fashion. The incision extends ventrally to the zygoma to allow full exposure of the temporal lobe. Here we present a right-sided approach. The skin and temporalis can be reflected together or separately to expose a craniotomy site that includes the coronal suture anteriorly, the asterion posteriorly, the midconvexity in the dorsal extent, and to the floor of the middle fossa ventrally.
SPEAKER: This patient has a preexisting ventricular shunt, which is preserved, disconnected, and protected. The bone flap is turned to maximize visualization, which ensures adequate disconnection and minimized tissue injury from extensive retraction.
SPEAKER: The dura is tacked to the bone to prevent the formation of postoperative epidural collections. The dura is opened in C-shaped fashion and reflected along a frontal temporal base. Five major disconnections are needed in order to successfully complete the operation. Resection of the medial temporoparietal lobe, disruption of the corona radiata and temporal white matter, a corpus callosotomy, disconnection of the basal frontal connections, and finally, removal of the insula.
SPEAKER: The sylvian fissure is identified. A pial cut is made in the dorsal superior temporal gyrus, and the temporal lobe is elevated from the pia overlying the vessels within the sylvian fissure. Here, the lateral temporal lobe is elevated from the insula laterally and the inferior circular sulcus is identified below. The frontal lobe is then gently retracted to expose the superior circular sulcus.
SPEAKER: This connects back to the inferior circular sulcus, which serves as a landmark for the temporal horn of the lateral ventricle. The temporal horn is opened to expose the mesial temporal structures. Cottonoids are used to prevent blood from entering the contralateral ventricular system. As the ventricle is exposed, several key anatomic landmarks are identified, including the hippocampus, amygdala, and choroidal point.
SPEAKER: The ventricle is unroofed completely to expose the rest of the hippocampal body and tail as it transitions into the fornix. Above the sylvian fissure, the corona radiata is divided to enter the lateral ventricle.
SPEAKER: Here, the corpus callosum can be visualized at the junction of the septum pellucidum and the ventricular roof. Again, a small cotton ball can be used to plug the foramen of Monro. The frontal parietal white matter should be resected posteriorly and around the posterior insula to connect the infra-sylvian dissection.
SPEAKER: Attention is then turned to the horizontal frontal fibers which lie anterior and superior to the insula. Attention to this area is particularly important, as it is frequently a site of residual connection that requires reoperation, especially when malformative of cortex is present in this region. The posterior basal frontal lobe is removed to expose the orbitofrontal pia, which is then coagulated and opened down to the olfactory nerve.
SPEAKER: Here, the gyrus rectus is identified and aspirated until the pia of the contralateral gyrus rectus is seen. Here, the origin of the A2 branches can be visualized and followed to the genu of the corpus callosum, which generally occurs as the arteries curve posteriorly into the A3 segment. This anatomical boundary is important to note, as it allows for ample disconnection at the genu without injurious extension into the hypothalamus ventral to the genu.
SPEAKER: Dissection should be subpial with preservation of as much as the vascular supply to the cortex left behind as possible to avoid postoperative issues with stroke and brain swelling. The curve of the genu can be confusing, and one must remember that two layers of gray matter and pia will be encountered during its aspiration. The corpus callosum should be disconnected at the junction of the roof of the ventricle and the septum pellucidum.
SPEAKER: Aspiration of the ipsilateral cingulate ensures a complete disconnection and makes postoperative imaging easier to interpret. The inferior edge of the falx is often seen and serves as an excellent anatomic reference during callosotomy. Branches of the anterior cerebral artery should be spared whenever possible. The surgeon must respect both arteries above the callosum, as it is difficult to tell which artery supplies the affected hemisphere.
SPEAKER: Care should be taken to completely disconnect the splenium. Review of the individual callosal anatomy, as seen on the preoperative MRI, helps as the callosal anatomy can vary depending on the etiology of the epilepsy. Attention is then turned to the mesial temporal structures which were previously exposed.
SPEAKER: The choroidal point is identified and the amygdala is dissected along the plane connecting the M1 segment of the MCA and the choroidal point. The remaining parahippocampus and uncus are then removed via subpial aspiration, being careful not to violate the mesial pia or injure the structures in the perimesencephalic cistern. The hippocampus is then reflected inferiorly and the choroidal fissure opened by aspiration of the fimbria and fornix.
SPEAKER: At this point, the hippocampal sulcus is identified and developed with further aspiration of the dentate gyrus. Once visualized, the hippocampal sulcus, including the hippocampal arteries and veins, are coagulated and divided. The hippocampus is then removed in one segment for pathological study. In this case, we now remove the lateral neocortical structures to allow further exposure of the posterior mesial temporal region.
SPEAKER: The lateral neocortex can also be removed early on during the exposure of the mesial structures at the beginning of the case by connecting sagittal and coronal cuts through the lateral ventricular sulcus along the collateral eminence. This can be an important tool to aid in surgical visualization and help to guarantee an adequate disconnection. The tail of the hippocampus is then followed posteriorly around the midbrain into the forniceal columns where it is truncated.
SPEAKER: Above the forniceal columns, note the relation of the splenium. This anatomical relationship allows inspection and complete disconnection of the callosum. The final step of the operation is removal of the insula.
SPEAKER: With care to preserve the vessels overlying, the gyri are gently aspirated with suction. Excessive removal of tissue can lead to disruption of the basal ganglia deep to the insula, which is usually identified by its speckled appearance and the incidence of diffuse bleeding on aspiration. Hemostasis is achieved with care to remove as much blood from the foramen of Monro as possible.
SPEAKER: A ventricular drain is placed into the subdural space in the ventricular cavity. The dura is then closed primarily. The shunt is reconnected. For patients with adjustable shunts, we typically turn the shunt to the highest resistance to decrease postoperative fluid flow through the system until the ventricular drain is removed between postoperative day 3 through 5.
SPEAKER: The bone is replaced and the muscle is reapproximated. A subgaleal drain is also placed and the skin is then closed. Patients are placed on an extended steroid taper after surgery and antiseizure medications are restarted at preoperative doses.
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