Name:
10.3171/2026.1.FOCVID25226_vid
Description:
10.3171/2026.1.FOCVID25226_vid
Thumbnail URL:
https://cadmoremediastorage.blob.core.windows.net/5cfc7402-6dfc-4046-9060-c9b462ff53f8/videoscrubberimages/Scrubber_403.jpg
Duration:
T00H10M30S
Embed URL:
https://stream.cadmore.media/player/5cfc7402-6dfc-4046-9060-c9b462ff53f8
Content URL:
https://cadmoreoriginalmedia.blob.core.windows.net/5cfc7402-6dfc-4046-9060-c9b462ff53f8/6. 25-226.mp4?sv=2019-02-02&sr=c&sig=ghUrmoDDxkg6K4G6Aest7mDHqbIvaXrSHA3Rz9jNPdM%3D&st=2026-09-20T19%3A26%3A23Z&se=2026-09-20T21%3A31%3A23Z&sp=r
Upload Date:
2026-09-20T19:31:23.3708136Z
Transcript:
Language: EN.
Segment:0 .
[MUSIC PLAYING]
SPEAKER: This video highlights fetoscopic myelomeningocele repair. Fetal myelomeningocele is a neural tube defect in which the spinal cord remains exposed leading to progressive neurologic injury throughout gestation. Myelomeningocele has a prevalence of 3 cases for every 10,000 births in the US and is associated with significant postnatal disability. It is the most common congenital defect of the central nervous system.
SPEAKER: Most fetuses with myelomeningocele have Chiari II malformation and are at high risk for hydrocephalus, often requiring ventriculoperitoneal shunting with significant morbidity. As shown in the MOMS trial, prenatal repair reduces shunt rates and improves motor outcomes compared with postnatal surgery. Fetoscopic repair provides these benefits while reducing maternal morbidity associated with open hysterotomy.
SPEAKER: At our institution, the fetoscopic repair is done with a multidisciplinary team, which includes pediatric surgery, maternal-fetal medicine, pediatric neurosurgery, OB anesthesia, nursing, and an intraoperative sonographer. In addition to demonstrating surgical technique, this video includes a preliminary summary of institutional outcomes. Outcomes were derived from a prospective single-center review of all fetoscopic myelomeningocele repairs from May 2019 through July 2025.
SPEAKER: Candidates were selected using the MOMS trial eligibility criteria. Preoperative evaluation includes detailed fetal imaging to document lesion level and morphology, confirm Chiari II malformation, and measure ventricular size. An example of a prenatal MR fetus is shown, which shows classic features associated with myelomeningocele, including concavity of the frontal bones or the "lemon sign" on the left, dilated lateral ventricles, and Chiari II malformation.
SPEAKER: Patients are admitted the night before surgery to complete preoperative labs, evaluation of maternal stability, and anesthesia assessment. On the day of the procedure, an epidural is placed and general anesthesia is induced. A Pfannenstiel incision with midline facial incision is performed, and the uterus is externalized. Amnioinfusion is performed.
SPEAKER: And stay sutures are placed around the intended port site in a box configuration. The first port is placed under ultrasound guidance using the Seldinger technique. After amnioreduction, the uterus is insufflated with carbon dioxide. Two additional ports are placed under direct visualization. A standard intramuscular fetal cocktail of vecuronium and fentanyl is administered.
SPEAKER: If indicated, a stay suture is then placed either cephalad or caudal to the lesion in order to help stabilize the fetus. Potential but very low risks include localized bleeding or skin injury at the entry point and a theoretical risk of membrane disruption, which we mitigate through careful placement under endoscopic visualization.
SPEAKER: Dissection begins circumferentially along the margins of the placode. Dissection proceeds along the lateral edges of the placode to free neural tissue. The neural placode is carefully released from surrounding tissues. Placode imbrication is not performed in our fetoscopic technique. While some postnatal repairs may include imbrication under open exposure, we prioritize atraumatic handling and efficient multilayer closure in utero due to tissue fragility and limited working space.
SPEAKER: Skin flaps are mobilized to prepare for tension-free closure. Transitional epithelium is excised. When hemostasis is required, monopolar cautery scissors are used sparingly at a low power setting of 10 watts for superficial bleeding points away from the placode.
SPEAKER: Tamponade and irrigation are preferred whenever possible. And direct contact with neural tissue is avoided. A collagen matrix is placed as an overlay dural substitute and is not sutured to native dura in our technique. Watertightness is achieved through subsequent multilayer closure. A central stitch is then placed to approximate the skin edges and relieve tension prior to final closure. The skin is closed using a running 4-0 V-Loc suture, creating a watertight repair.
SPEAKER: Here we show postoperative images from days of life 1 and 3 demonstrating durable watertight closure with no cerebrospinal fluid leak. In the second clip, a myeloschisis defect is demonstrated, highlighting techniques for large defects with limited skin mobility.
SPEAKER: Dissection is performed along the lateral margins to fully release the placode. Circumferential release is achieved.
SPEAKER: Skin flaps exhibit limited medial mobility, precluding primary closure. The skin edges lie significantly lateral relative to the placode. A relaxing incision is required to achieve a tension-free closure. A relaxing incision is made along the flank to improve tissue mobility. The dissection proceeds down to the muscle and fascial layers.
SPEAKER: The relaxing incision is complete. A dural substitute patch is placed over the exposed placode. Interrupted sutures are used to approximate the myofascial layer. Skin is closed using a 4-0 V-Loc Maxon suture in a running fashion.
SPEAKER: A tension-free multilayer closure is completed. Postop images from day of life 1 and 9 demonstrate durable closure. The final clip demonstrates repair of a large myelomeningocele defect. The neural placode is circumferentially released. Dissection is initiated at the superior aspect of the placode, which is handled gently using atraumatic instruments and no traction.
SPEAKER: A moist operative field and continuous endoscopic visualization are maintained to protect the ascending spinal cord and vascular arcade. Transitional epithelium is excised. Skin flaps are elevated and mobilized to facilitate closure. The myofascial layer is mobilized to create an additional reconstructive layer.
SPEAKER: A DuraGen collagen matrix is placed over the placode. Interrupted Vicryl sutures are used to close the myofascial layer. Skin closure is completed using horizontal mattress and interrupted sutures.
SPEAKER: A stable, watertight multilayer repair is achieved. A postoperative image from day of life 4 demonstrates durable closure. Postnatal care is coordinated through a multidisciplinary spina bifida clinic involving pediatric surgery, neurosurgery, neurology, physiatry, and urology. Early outcomes from our first 17 patients demonstrate excellent fetal neurologic results.
SPEAKER: At the time of video preparation, the average patient age is approximately 3 years, with all but 1 patient followed for more than 1 year. Our 12-month VP shunt rate is 12%, compared with 40% after open repair in the MOMS trial and 42% reported in a meta-analysis of fetoscopic studies. Furthermore, 82% of patients in our cohort exhibited reversal of hindbrain herniation, compared to the 36% rate in the MOMS trial.
SPEAKER: Maternal outcomes in our cohort were also favorable, with no cases of uterine dehiscence or placental abruption. An example of a postnatal MRI is shown at 1 year of life, which demonstrated reversal of hindbrain herniation. In conclusion, fetoscopic myelomeningocele repair using an externalized uterine technique provides a minimally invasive alternative to open prenatal surgery and is a safe option for carefully selected patients.
SPEAKER: Tailored strategies, including relaxing incisions and myofascial mobilization, allow successful reconstruction of large defects. The repair also highlights the importance of a highly collaborative multidisciplinary team, each contributing essential expertise.
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