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Clinical applications of nanomedicine research with Sourav Bhattacharjee
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Clinical applications of nanomedicine research with Sourav Bhattacharjee
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T00H09M28S
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https://cadmoreoriginalmedia.blob.core.windows.net/89f6dfe2-b659-442f-b8e1-20d975e483c3/Sourav Bhattacharjee video 2.mp4?sv=2019-02-02&sr=c&sig=43hYTIQU6hVja307k%2BFL%2BXIUouBHGL1%2F2iJtXtggPq4%3D&st=2024-11-23T04%3A22%3A48Z&se=2024-11-23T06%3A27%3A48Z&sp=r
Upload Date:
2021-03-11T00:00:00.0000000
Transcript:
Language: EN.
Segment:1 How excited are you about the future of nano-drug delivery systems, and where would you imagine them being used the most?.
[MUSIC PLAYING]
SOURAV BHATTACHARJEE: Well, I'm incredibly excited. But at the same, time I'm cautious as well. I mean, if you look into the history of nanotechnology and how it has evolved over the last couple of decades, at least, for me, there has never been a shred of doubt that it's an enabling technology with incredible potential. But I think more and more we are realizing sort of a rather discomforting fact that nanotechnology, in spite of all its amazing potential, might not evolve as a disruptive technology like which we envisioned or got excited what we'd expect.
SOURAV BHATTACHARJEE: Rather, what nanotechnology is slowly evolving into is a sort of a more refinement, or it is very good in refining or improving a lot of current technologies. And that doesn't mean it's a discouraging statement. Instead, there is a lot of potential, and there are new frontiers that are slowly and gradually opening up for nanomedicine or drug delivery purposes. For example, I'm currently extremely excited about a very emerging field which I think needs a lot of investment and a lot of-- it makes a lot of curiosity as well into the research communities the use of nanomaterials as antimicrobials.
SOURAV BHATTACHARJEE: And I know, it's so important to everyone in the literature, that antimicrobial resistance is rampant now. And that's a serious challenge for health care sector. And it's really widespread even for tropical countries, where infectious diseases are reemerging. So nanomaterials can be an amazing tool to circumvent those challenges and give us new opportunities to address those issues which are re-emerging at a global scale.
SOURAV BHATTACHARJEE: And I think those are the exciting bits. And so if you ask me, I would like to have new frontiers opening. And as far as drug delivery is concerned, I believe it will certainly improve a lot of the existing technologies, if not, bring certain new things, which I'm very much looking forward.
Segment:2 What diseases is nanomedicine research being used?.
SOURAV BHATTACHARJEE: [MUSIC PLAYING] Nanomedicines are being used for a wide variety of diseases.
SOURAV BHATTACHARJEE: But I think just like the previous question, one of the major troche areas of the disease is in cancer. And that's pretty popular feeling of equalization of nanomedicine. What I would like to see though, and it's already coming up, that nanomaterials are being used for drug delivery, and diagnostic purposes, and maybe imaging purposes as well, and certain other diseases. For example, endocrinal disease, diabetes, for example.
SOURAV BHATTACHARJEE: And I would like to also see getting more and more used for genetic diseases or inherited disorders, for example. And there are already publications which show that nanomaterials can be used as a very efficacy's vector of genetic materials like DNA, RNA. And, again, it's an active research field, so we are learning something new every day.
SOURAV BHATTACHARJEE: I would like to see more and more applications there, and it's emerging, so that's the really good news. Another thing that is again an emerging field is the application of nanomaterials for tissue engineering. And nanomaterials, again, because of those unprecedented properties which can include conductivity, or paramagnetism, or neuroscience, I mean, nanomaterials can be quite conducive for developing new age biomaterials which can be used for different other procedures, or implants, or prosthetics.
SOURAV BHATTACHARJEE: I think that's a really, really exciting field that I'm looking forward. And I want it to be used more and more there. And I have already said my fascination about using nanomaterials as antimicrobials given the real challenge that the health care sector is facing now, probably because of this widespread antimicrobial resistance. I think nanomaterials are getting used, but it needs much more attention than what it is getting now, which I hope our future will be.
Segment:3 How do you envisage nanomedicine being used in treating cancer?.
SOURAV BHATTACHARJEE: [MUSIC PLAYING] In fact, if you look from the inception of nanomedicine term-- I mean, nanomedicine or this drug delivery platforms with nanomaterials has always been used for cancer treatment. And when I say treatment of cancer, there is a wide variety of uses now.
SOURAV BHATTACHARJEE: It will be difficult to cover them all within the scope of just one interview, because there is an entire spectrum of research that is going on. I'll just give you a simple example, because maybe examples work better than just explaining. I mean, doxil, which is taken as arguably the most successful product that has come out of nanomedicine research is a liposomal preparation of doxorubicin, which is a very popular anti-cancer drug.
SOURAV BHATTACHARJEE: But if you look into doxorubicin when it was applied to cancer patients, it has tremendous amount of systemic toxicity, and there were a lot of side effects. Cardiotoxicity, for example, was one of the major limiting factors of using doxorubicin. But when these doxorubicin, the same doxorubicin drug which is otherwise toxic, they were encapsulated within liposomes with nanoparticles, encapsulated nano-formulations, that cardiotoxicity part, in fact, with some allied toxicity side effects of doxorubicin, they actually diminished.
SOURAV BHATTACHARJEE: So imagine the magic by just putting those drugs in an encapsulated format within nanomaterials have taken out or largely addressed the issues that we always had with doxorubicin. And that's the incredible things that simple tweaking of technology can do. So in cancer, this is one of the brightest examples of how nanotechnology can be used. Now, what we are doing also is, and I think there is a lot of research going on throughout the world, that cancer tissue, because of its unique pathology, is different from, of course, healthy tissue.
SOURAV BHATTACHARJEE: And there are a lot of things. For example, there are certain receptors which are overexpressed in cancer cells, but it is not the case of normal healthy tissues. So what we are trying to do is we are trying to utilize this unique features of cancer tissue, and we are trying to engineer nanoparticles, which will utilize the skills, physical chemical use in cancer tissue, and will help in drug delivery.
SOURAV BHATTACHARJEE: And we typically call it targeted nano-formulations. The ambition with these formulations are that they will target specific cancerous tissues while living the normal healthy tissue aside so that the treatment will be delivered in a site-specific and precise manner, which has always been the dream, and we are working towards that. Apart from that, nanomaterials are incredible and unprecedented materials because of their very small sizes, which also makes them suitable sometimes, at times, for biomedical imaging, and they can provide with certain edge over the contemporary imaging agents.
SOURAV BHATTACHARJEE: So what we can do is we can combine this drug delivery perspective with bioimaging capability. And what we are trying to develop is multimodal platforms, theranostic platforms. I think that's very exciting. And if you ask me, I think that's where the future is. So there is an entire area of different diagnostic and therapeutic platforms emerging with nanomedicine, and it's a fast evolving field.
SOURAV BHATTACHARJEE: And I'm pretty much intrigued with it, so I'm pretty much-- I'm part of this entire evolution, and I look forward to some great future. [MUSIC PLAYING]
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