Name:
In Focus: Scalability
Description:
In Focus: Scalability
Thumbnail URL:
https://cadmoremediastorage.blob.core.windows.net/a664a396-a1e7-4044-a8be-91e722eb941c/videoscrubberimages/Scrubber_8.jpg
Duration:
T00H02M16S
Embed URL:
https://stream.cadmore.media/player/a664a396-a1e7-4044-a8be-91e722eb941c
Content URL:
https://cadmoreoriginalmedia.blob.core.windows.net/a664a396-a1e7-4044-a8be-91e722eb941c/RMN 2023 Q4 PromoCell In Focus Scalability - Video FINAL.mp4?sv=2019-02-02&sr=c&sig=QX3ZuW0LO1%2BFNm%2Ffp166ukEDpejAYpFVAHYlAYD8x2o%3D&st=2024-05-12T04%3A18%3A59Z&se=2024-05-12T06%3A23%3A59Z&sp=r
Upload Date:
2023-11-08T00:00:00.0000000
Transcript:
Language: EN.
Segment:0 .
SPEAKER: Hello, and welcome to RegMedNet. This month, we are focusing on scaling up cell culture. In regenerative medicine, stem cell expansion is crucial for generating an adequate number of cells. High cell yields are often required for various applications. And the demand for cell numbers can vary widely, depending on the specific type of therapy, the disease or condition being treated, and the stage of clinical development.
SPEAKER: For instance, in early phase trials, therapeutic doses may involve thousands to hundreds of thousands of cells. In many established cell therapies such as CAR-T cell therapy, the therapeutic dose often falls in the range of millions to tens of millions of cells. Cell expansion allows researchers and cell therapy developers to generate the necessary quantity of cells for their applications.
SPEAKER: However, cell expansion comes with its challenges. Particularly when transitioning from small scale research to clinical or commercial scale manufacturing. In this in-focus feature in association with PromoCell, we'll explore some of the challenges involved with cell expansion, and the high costs associated with it. These challenges include potential issues like the loss of differentiation, heterogeneity, genomic instability, senescence, and risks such as contamination, all of which can impact the quality, safety, and success of the expanded cells.
SPEAKER: We'll delve into how leveraging specialized expertise through a tailored cell expansion service can help address these limitations, while also providing careful monitoring and rigorous quality control, saving valuable time and resources, as well as reducing costs. Join the conversation today at regmednet.com or follow the discussion on X, Facebook, and LinkedIn. We'll see you there.
SPEAKER: