Name: Retinal Vein Occlusion
Uploaded: 2024-10-16T00:00:00.0000000
Duration: T00H02M33S
Description: Retinal Vein Occlusion

Name: Retinal Vein Occlusion

Description: Retinal Vein Occlusion

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Duration: T00H02M33S

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Content URL: https://cadmoreoriginalmedia.blob.core.windows.net/b1024d7b-95a8-4dd7-9b98-b97e043c5a8e/01_RVO Overview_09Oct24.mp4?sv=2019-02-02&sr=c&sig=%2BCOftix%2BGL0egjSBc6OVqD3x6WdeUtiP1FijFeD1Unc%3D&st=2024-11-21T10%3A11%3A14Z&se=2024-11-21T12%3A16%3A14Z&sp=r

Upload Date: 2024-10-16T00:00:00.0000000

Transcript: Language: EN.
Segment:0 .
[MUSIC PLAYING]
SPEAKER: Retinal vein occlusion, or RVO, is understood to be caused by the formation of a blood clot in a retinal vein. The backlog of blood flow results in a buildup of pressure within the vein, which eventually leads to bleeding into the retina.
SPEAKER: RVO is a multifactorial disease, but VEGF-A and Ang-2 are two key players. An increase of these factors leads to vascular instability, inflammation, and leakage, resulting in neovascularization, hypoxia, hemorrhage, and upregulation of pro-inflammatory cytokines. RVO is classified into three main types based on the specific vein occluded: branch RVO, central RVO, and hemi-retinal RVO.
SPEAKER: RVO is experienced by patients with an acute onset, with potential long-term consequences. Patients may be asymptomatic, but symptoms can be rapid and include painless reduction of vision. The degree of impairment depends on the severity of the occlusion. Some patients may experience vision distortion or a shadow in the vision. Left untreated, RVO can cause permanent vision, impairment, blindness, and other complications.
SPEAKER: Key risk factors include increased age, diabetes, hyperlipidemia, cardiovascular conditions, and lifestyle factors, such as smoking. As the population ages and the prevalence of cardiovascular conditions rises, the incidence of RVO is expected to increase.
SPEAKER: People living with RVO experience a high burden of disease with negative impacts on quality of life. Treatment with intravitreal injections requires frequent visits, which results in high health care costs, decreased productivity, and an increased burden on patients and carers. Patients often receive fewer injections than needed, leading to worse vision outcomes. To reduce the burden on patients and health care systems, new therapies which address the complex disease mechanisms underlying RVO are needed.
SPEAKER: These therapies also need to be more durable than existing therapies to decrease the frequency of injections while improving outcomes. [MUSIC PLAYING]

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