Name:
In Focus: packaging and producer cell lines – RegMedNet
Description:
In Focus: packaging and producer cell lines – RegMedNet
Thumbnail URL:
https://cadmoremediastorage.blob.core.windows.net/d331b822-b673-40c0-8432-8c242e10cd6b/videoscrubberimages/Scrubber_5.jpg
Duration:
T00H01M22S
Embed URL:
https://stream.cadmore.media/player/d331b822-b673-40c0-8432-8c242e10cd6b
Content URL:
https://cadmoreoriginalmedia.blob.core.windows.net/d331b822-b673-40c0-8432-8c242e10cd6b/OXGENE Sharon - In Focus V2.mp4?sv=2019-02-02&sr=c&sig=DlQm6Z53anH4BEGRX2G%2Bfezu2XH9ALNgLYpIR0q5s8U%3D&st=2024-05-04T20%3A01%3A36Z&se=2024-05-04T22%3A06%3A36Z&sp=r
Upload Date:
2020-10-30T00:00:00.0000000
Transcript:
Language: EN.
Segment:0 .
SPEAKER: Hello, and welcome to RegMedNet. This month we're putting packaging and producer cell lines in focus. When it comes to developing cell therapies, lentiviral vectors are often a popular choice for transient transfection. However, this method can be expensive, difficult to reproduce at larger scales and can result in contamination of the lentiviral preparation. Lentiviral production with packaging and producing cell lines offers an attractive alternative for this as they already have elements of the lentiviral packaging system embedded in the cell's genome.
SPEAKER: Thus, this reduces the need for plasmid transfection and decreases the complexity of the overall process, resulting in a lower overall risk for human error and batch- to-batch variation. Moreover, this enables the cost involved for large-scale manufacturing of lentiviral vectors to be decreased. In this feature, we will explore the advantages that packaging and producer cell lines have, including what applications would be most appropriate for their use.
SPEAKER: We will also be speaking to experts from OXGENE to discuss how the needs of cell therapy manufacturers have changed over recent years with regards to the use of lentiviral vectors. Join the conversation today at www.regmednet.com. Plus you can also join us on Twitter, Facebook and LinkedIn. I'll see you there. [MUSIC PLAYING]