Name:
Fluorescence-guided craniotomy of glioblastoma using panitumumab-IRDye800
Description:
Fluorescence-guided craniotomy of glioblastoma using panitumumab-IRDye800
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Duration:
T00H02M54S
Embed URL:
https://stream.cadmore.media/player/d764cef8-055a-451c-b798-8db6a84a1d96
Content URL:
https://cadmoreoriginalmedia.blob.core.windows.net/d764cef8-055a-451c-b798-8db6a84a1d96/21-201.mp4?sv=2019-02-02&sr=c&sig=l2%2Fk%2BfZ2CV5asKmCp9reCDPVMfMU0umhKdScg4HQquI%3D&st=2024-05-04T09%3A30%3A15Z&se=2024-05-04T11%3A35%3A15Z&sp=r
Upload Date:
2021-12-06T00:00:00.0000000
Transcript:
Language: EN.
Segment:0 .
[MUSIC PLAYING]
SPEAKER: Fluorescence-guided craniotomy of glioblastoma using panitumumab-IRDYE800 by Drs. Quan Zhou and Gordon Li. Contrast-enhancing glioma in the left temporal lobe of patient was found on preoperative MRI. 50 mg of near-infrared labeled EGFR antibody, panitumumab-IRDYE800, was infused without preloading of unlabeled antibody 2 days before surgery within the imaging window of 1–5 days.
SPEAKER: On the day of surgery, patient's skull was removed to reveal dura. The tumor is located immediately beneath the intact dura. A portable handheld device was used to acquire near-infrared images of the surgical field.
SPEAKER: Next, the dura was open to expose the tumor under white light illumination. Intraoperative Neuronavigation mapped the location of tumor surface until stereotactic coordinates of preoperative MRI scan. Exposed tumor was then illuminated with near-infrared light, and fluorescence signal was collected with the handheld imager.
SPEAKER: Residual tumor was identified with high fluorescence intensity and removed from resection cavity. Minimal fluorescence likely from nonenhancing tumor remained in the final wound bed outside the contrast-enhancing margin on MRI, and thus not removed per standard-of-care protocol. Resected tumor pieces were imaged in a near-infrared instrument, free from ambient light.
SPEAKER: Postoperative MRI confirmed gross-total resection of glioblastoma.