Name: Organ-on-a-chip for drug development
Uploaded: 2025-04-15T00:00:00.0000000
Duration: T00H02M29S
Description: Organ-on-a-chip for drug development

Name: Organ-on-a-chip for drug development

Description: Organ-on-a-chip for drug development

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Upload Date: 2025-04-15T00:00:00.0000000

Transcript: Language: EN.
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Drug development is a notoriously slow, complex, and costly process, with over 90% of drug candidates failing before reaching the market. A major cause of this inefficiency is the reliance on traditional models, such as 2D cell cultures and animal models. These models often fail to accurately predict human responses, so drugs that appear to be safe and effective in animals turn out to be harmful or ineffective in humans, while potentially effective compounds never make it past this stage.
This is where organ-on-a-chip or OOC technology comes in. OOC devices are engineered systems that replicate the physiological, biochemical, and mechanical properties of human organs. These microdevices are composed of a clear, flexible polymer that contains microfluidic channels lined with living human organ cells and human blood vessel cells. Flows through the channels to simulate blood circulation, oxygen exchange, and nutrient delivery by integrating biomechanical forces, such as cyclic suction in a lung on a chip model to mimic breathing.
The models allow cells to behave as they would inside the body, providing unprecedented biological relevance. As a result, OOCs can more accurately model human responses to drugs, toxins, and disease conditions, providing an alternative way to screen drug candidates in the early stages for efficacy and toxicity, reducing the risk of late stage failures. By linking multiple OOCs, researchers can simulate multi-organ interactions, modeling how a drug travels through the body and providing a more comprehensive understanding of pharmacokinetics and pharmacodynamics, with the potential to enhance clinical translation and reduce reliance on animal models.
Organ on a chip technology is revolutionizing biomedical research. To learn more about the use of OOCs in drug development, check out our In Focus on the topic.

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